Polypharmacology-based ceritinib repurposing using integrated functional proteomics
نویسندگان
چکیده
منابع مشابه
A Structural and Functional View of Polypharmacology
The similarity property principle states that similar compounds have similar properties. In this study, we demonstrate that validity this principle holds well when the drug targets are protein domains. We leverage the similarity property principle to explore the druggability of CATH-FunFams, a type of protein domain and we use the associations between drugs and CATH-FunFams to explore drug poly...
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Polypharmacology has emerged as a new theme in drug discovery. In this paper, we studied polypharmacology using a ligand-based target fishing (LBTF) protocol. To implement the protocol, we first generated a chemogenomic database that links individual protein targets with a specified set of drugs or target representatives. Target profiles were then generated for a given query molecule by computi...
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Achieving an understanding of the functional role of all proteins expressed by a complex organism will require the development of methods that enable the rapid monitoring of protein function on a global scale. Current genomics and proteomics technologies fall short of this goal since they measure only the relative abundance of transcripts and proteins, respectively. Recent efforts in several la...
متن کاملFunctional proteomics.
BACKGROUND With the increase in the number of genome sequencing projects, there is a concomitant exponential growth in the number of protein sequences whose function is still unknown. Functional proteomics constitutes an emerging research area in the proteomic field whose approaches are addressed towards two major targets: the elucidation of the biological function of unknown proteins and the d...
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1. Ronald L. Hayes. An integrated platform for discovery and preclinical/clinical validation of biomarkers of brain injury. CHI Biomarker Validation meeting, San Francisco, Feb. 2005. 2. Linda Papa, Jose Pineda, Steve Lewis, Kevin Wang, Jason Demery, Shelley Heaton, Joe Tepas and Ronald Hayes. Levels of alpha-II spectrin breakdown products in human CSF and outcome after severe traumatic brain i...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2017
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.2489